[Genetics and present therapy options in Parkinson's disease: a review].
Identifieur interne : 000272 ( Main/Exploration ); précédent : 000271; suivant : 000273[Genetics and present therapy options in Parkinson's disease: a review].
Auteurs : Benjamin Bereznai [Hongrie] ; Mária Judit MolnarSource :
- Ideggyógyászati szemle [ 0019-1442 ] ; 2009.
Descripteurs français
- KwdFr :
- Antiparkinsoniens (usage thérapeutique), Association thérapeutique (méthodes), Dépistage génétique (MeSH), Humains (MeSH), Maladie de Parkinson (diagnostic), Maladie de Parkinson (génétique), Maladie de Parkinson (thérapie), Maladie de Parkinson (traitement médicamenteux), Musicothérapie (MeSH), Protein kinases (génétique), Protein-Serine-Threonine Kinases (génétique), Protéines et peptides de signalisation intracellulaire (génétique), Protéines oncogènes (génétique), Prédisposition génétique à une maladie (MeSH), Psychothérapie (MeSH), Stimulation cérébrale profonde (MeSH), Techniques de physiothérapie (MeSH), Thérapie génétique (MeSH), Thérapie par la danse (MeSH), Thérapie par la relaxation (MeSH), Ubiquitin-protein ligases (génétique), alpha-Synucléine (génétique).
- MESH :
- diagnostic : Maladie de Parkinson.
- génétique : Maladie de Parkinson, Protein kinases, Protein-Serine-Threonine Kinases, Protéines et peptides de signalisation intracellulaire, Protéines oncogènes, Ubiquitin-protein ligases, alpha-Synucléine.
- méthodes : Association thérapeutique.
- thérapie : Maladie de Parkinson.
- traitement médicamenteux : Maladie de Parkinson.
- usage thérapeutique : Antiparkinsoniens.
- Dépistage génétique, Humains, Musicothérapie, Prédisposition génétique à une maladie, Psychothérapie, Stimulation cérébrale profonde, Techniques de physiothérapie, Thérapie génétique, Thérapie par la danse, Thérapie par la relaxation.
English descriptors
- KwdEn :
- Antiparkinson Agents (therapeutic use), Combined Modality Therapy (methods), Dance Therapy (MeSH), Deep Brain Stimulation (MeSH), Genetic Predisposition to Disease (MeSH), Genetic Testing (MeSH), Genetic Therapy (MeSH), Humans (MeSH), Intracellular Signaling Peptides and Proteins (genetics), Music Therapy (MeSH), Oncogene Proteins (genetics), Parkinson Disease (diagnosis), Parkinson Disease (drug therapy), Parkinson Disease (genetics), Parkinson Disease (therapy), Physical Therapy Modalities (MeSH), Protein Kinases (genetics), Protein-Serine-Threonine Kinases (genetics), Psychotherapy (MeSH), Relaxation Therapy (MeSH), Ubiquitin-Protein Ligases (genetics), alpha-Synuclein (genetics).
- MESH :
- chemical , genetics : Intracellular Signaling Peptides and Proteins, Oncogene Proteins, Protein Kinases, Protein-Serine-Threonine Kinases, Ubiquitin-Protein Ligases, alpha-Synuclein.
- chemical , therapeutic use : Antiparkinson Agents.
- diagnosis : Parkinson Disease.
- drug therapy : Parkinson Disease.
- genetics : Parkinson Disease.
- methods : Combined Modality Therapy.
- therapy : Parkinson Disease.
- Dance Therapy, Deep Brain Stimulation, Genetic Predisposition to Disease, Genetic Testing, Genetic Therapy, Humans, Music Therapy, Physical Therapy Modalities, Psychotherapy, Relaxation Therapy.
Abstract
In the past years, six monogenic forms of Parkinson disease have clearly been associated with this movement disorder. The most frequent forms are LRRK2- and Parkin-associated Parkinson disease. Currently, a genetic diagnosis does not change the therapy, the genes involved in genetic Parkinson disease help to understand the underlying pathophysiologic mechanisms of Parkinson disease. Beside the overview of the molecular-genetic basis, we give a review about genetic testing, pharmacological and other multidisciplinary treatment options.
PubMed: 19579663
Affiliations:
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Le document en format XML
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(MeSH)</term><term>Ubiquitin-Protein Ligases (genetics)</term><term>alpha-Synuclein (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antiparkinsoniens (usage thérapeutique)</term><term>Association thérapeutique (méthodes)</term><term>Dépistage génétique (MeSH)</term><term>Humains (MeSH)</term><term>Maladie de Parkinson (diagnostic)</term><term>Maladie de Parkinson (génétique)</term><term>Maladie de Parkinson (thérapie)</term><term>Maladie de Parkinson (traitement médicamenteux)</term><term>Musicothérapie (MeSH)</term><term>Protein kinases (génétique)</term><term>Protein-Serine-Threonine Kinases (génétique)</term><term>Protéines et peptides de signalisation intracellulaire (génétique)</term><term>Protéines oncogènes (génétique)</term><term>Prédisposition génétique à une maladie (MeSH)</term><term>Psychothérapie (MeSH)</term><term>Stimulation cérébrale profonde (MeSH)</term><term>Techniques de physiothérapie (MeSH)</term><term>Thérapie génétique (MeSH)</term><term>Thérapie par la danse (MeSH)</term><term>Thérapie par la relaxation (MeSH)</term><term>Ubiquitin-protein ligases (génétique)</term><term>alpha-Synucléine (génétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Intracellular Signaling Peptides and Proteins</term><term>Oncogene Proteins</term><term>Protein Kinases</term><term>Protein-Serine-Threonine Kinases</term><term>Ubiquitin-Protein Ligases</term><term>alpha-Synuclein</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Maladie de Parkinson</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="genetics" 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xml:lang="fr"><term>Antiparkinsoniens</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Dance Therapy</term><term>Deep Brain Stimulation</term><term>Genetic Predisposition to Disease</term><term>Genetic Testing</term><term>Genetic Therapy</term><term>Humans</term><term>Music Therapy</term><term>Physical Therapy Modalities</term><term>Psychotherapy</term><term>Relaxation Therapy</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Dépistage génétique</term><term>Humains</term><term>Musicothérapie</term><term>Prédisposition génétique à une maladie</term><term>Psychothérapie</term><term>Stimulation cérébrale profonde</term><term>Techniques de physiothérapie</term><term>Thérapie génétique</term><term>Thérapie par la danse</term><term>Thérapie par la relaxation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In the past years, six monogenic forms of Parkinson disease have clearly been associated with this movement disorder. The most frequent forms are LRRK2- and Parkin-associated Parkinson disease. Currently, a genetic diagnosis does not change the therapy, the genes involved in genetic Parkinson disease help to understand the underlying pathophysiologic mechanisms of Parkinson disease. Beside the overview of the molecular-genetic basis, we give a review about genetic testing, pharmacological and other multidisciplinary treatment options.</div></front></TEI><affiliations><list><country><li>Hongrie</li></country><region><li>Hongrie centrale</li></region><settlement><li>Budapest</li></settlement></list><tree><noCountry><name sortKey="Molnar, Maria Judit" sort="Molnar, Maria Judit" uniqKey="Molnar M" first="Mária Judit" last="Molnar">Mária Judit Molnar</name></noCountry><country name="Hongrie"><region name="Hongrie centrale"><name sortKey="Bereznai, Benjamin" sort="Bereznai, Benjamin" uniqKey="Bereznai B" first="Benjamin" last="Bereznai">Benjamin Bereznai</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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